Manganous-manganic oxide-lactalbumin nanosphere and preparation and application thereof

• Main Authors: ZHU CHUNLING, XIE ZENGHONG, LIN XUCONG, CAO TING
• Format: Patent
• Language: Chinese; English
• Published: 07.11.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention belongs to the field of nanomaterial preparation and biological medicine and particularly relates to a manganous-manganic oxide-lactalbumin (Mn3O4-LA) nanosphere and preparation and an application thereof. The Mn3O4-LA nanosphere is prepared through self-assembly of oleic acid-modified hydrophobic Mn3O4 nanoparticles and alpha-LA after enzyme hydrolysis and DTT treatment through hydrophobic interaction, wherein the mean dimension is 120-140nm, the surface is negatively charged and the dispersity in a water phase is good. The obtained Mn3O4-LA nanosphere has a nuclear magnetic imaging function, is capable of loading hydrophobic and/or hydrophilic drug molecules, and can be used for preparing a diagnosis and treatment agent integrating nuclear magnetic imaging diagnosis and drug transportation. 本发明属于纳米材料制备和生物医学领域，具体涉及种四氧化三锰-乳白蛋白（MnO-LA）纳米球及其制备与应用。所述MnO-LA纳米球是由油酸修饰的疏水性MnO纳米颗粒与酶水解、DTT处理后的α-LA通过疏水作用自组装而成；其平均尺寸为120~140nm，表面带负电，在水相中分散性良好。本发明所得MnO-LA纳米球不仅具有核磁成像功能，且其可负载疏水性和/或亲水性药物分子，能够用于制备集核磁成像诊断及药物传输为体的