PCSK9 (proprotein convertase subtilisin kexin type 9) binding protein and application thereof

• Main Author: SHAO XIONG WANG
• Format: Patent
• Language: Chinese; English
• Published: 20.10.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention relates to a PCSK9 (proprotein convertase subtilisin kexin type 9) binding protein and an application thereof and provides a binding protein containing unique complementary determining region and capable of being specifically bound with PCSK9. The binding protein can be specifically bound with PCSK9 and effectively inhibit functions of PCSK9, reduce LDL (low-density lipoprotein) cholesterol level and can be applied to treatment of diseases related with PCSK9 functions or affected by the PCSK9 functions. 本发明涉及前蛋白转化酶枯草溶菌素kexin 9型的结合蛋白及其应用。本发明提供了含有独特的互补决定区的特异性结合前蛋白转化酶枯草溶菌素kexin 9型(PCSK9)的结合蛋白，其能与PCSK9特异性结合并有效抑制PCSK9的功能、降低血浆中LDL胆固醇水平，可以应用于治疗与PCSK9功能相关或者是受到PCSK9功能影响的疾病。