[beta]-lactamases compounds and their use

• Main Authors: APPU ARAVIND, NARAYANAN SHRIDHAR, UDAYAMPALAYAM PALANISAMY SENTHILKUMAR, BALASUBRAMANIAN GOPALAN, PERIASAMY HARIHARAN, MANICKAM SENTHILNATHAN, PAUL-SATYASEELA MANEESH
• Format: Patent
• Language: Chinese; English
• Published: 20.10.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Described herein are compounds and use thereof in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as [beta]-lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of ss-lactamases. The compounds restore/potentiate the activities of [beta]-lactam antibiotics against carbapenemases. The compounds find use in diagnostic method for detecting [beta]-lactamases. 本发明涉及化合物及其用途。本发明公开了化合物及其用于治疗传染病的用途。本发明描述的式(I)化合物，其衍生物、类似物、互变异构形式、立体异构体、多晶型物、溶剂合物、药学上可接受的盐和药物组合物也用作β-内酰胺酶抑制剂，其恢复/增强合适的抗生素试剂的抗生谱。式(I)化合物作为β-内酰胺酶抑制剂。这些化合物恢复/增强β-内酰胺抗生素抗碳青霉烯的活性。这些化合物可用于检测β-内酰胺酶的诊断方法中。