Preparation method of Iopromide and application of an intermediate thereof

The invention relates to the field of iopromide. In order to solve the technical problems of the prior art that methods of preparing Iopromide are high purification difficulty, has complex steps and causes environmental pollution, the invention provides a preparation method of Iopromide and applicat...

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Bibliographic Details
Main Authors GAO HAIFENG, YANG JIUCAI, GAO QUAN, PENG KAIJIN, LU LINGJIANG, WU JICHAO
Format Patent
LanguageChinese
English
Published 17.10.2017
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to the field of iopromide. In order to solve the technical problems of the prior art that methods of preparing Iopromide are high purification difficulty, has complex steps and causes environmental pollution, the invention provides a preparation method of Iopromide and application of its intermediate; the preparation method comprises the steps of a, protecting by methoxy acetic anhydride, to be specific, a compound of formula (10) is allowed to react with methoxy acetic anhydride to obtain a compound of formula (II); b, allowing the compound of formula (10) to react with 3-methylamino-1,2-propanediol, hydrolyzing the product, and purifying to obtain Iopromide at a compound of formula (12); c, allowing the compound of step (12) to react with an iodization reagent to obtain iopromide of step (1); application of iopromide prepared via the compound of formula (10), (11) or (12) is also provided. The preparation method of iopromide has decreased environmental pollution and short reaction time
Bibliography:Application Number: CN20171459413