SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS

• Main Authors: CASAUBON REBECCA, KOPPETSCH KARSTEN, SZCZEPANKIEWICZ BRUCE G, CALDWELL RICHARD DANA, OALMANN CHRISTOPHER, BLUM CHARLES A, DISCH JEREMY S, NG PUI YEE, MILLER WILLIAM HENRY, FOX RYAN MICHAEL, PERNI ROBERT B, WHITE BRIAN H
• Format: Patent
• Language: Chinese; English
• Published: 26.09.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. 本发明涉及新的取代的桥环脲化合物、对应的相关类似物、药物组合物以及它们的使用方法。调节沉默调节蛋白的本发明化合物可以用于增加细胞寿命，以及治疗和/或预防广泛的疾病和病症，其包括但不限于，例如，与老化或应激有关的疾病或病症、糖尿病、肥胖症、神经变性疾病、心血管疾病、凝血障碍、炎症、癌症、和/或潮红，以及将得益于增加线粒体活性的疾病或病症。本发明还涉及包含调节沉默调节蛋白的化合物和其它治疗剂的组合物。