Dobby polyethylene glycol and its active derivative

• Main Authors: ZHAO XUAN, LIN MEINA, WEI ZHEN, ZHU ZHENGANG
• Format: Patent
• Language: Chinese; English
• Published: 26.09.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention belongs to the technical field of a macromolecular function material, and particularly relates to a novel narrow-distributed/high-purity dobby polyethylene glycol formed by using polyhydric alcohol glyceryl ether as initiator to polymerize ethylene oxide, and its active derivative. The dobby polyethylene glycol has a structure of a general formula II, wherein B is polyhydric alcohol group and n is integer from 3 to 22; PEG is the same or different -(OCH2CH2)m-, the mean value of m is integer ranged from 3 to 250; number-average molecular weight of the dobby polyethylene glycol is 1500-80000. The invention further provides gel formed by active derivative of the narrow-distributed/high-purity dobby polyethylene glycol, a drug composition formed by the gel and the drug molecule and its application in drug preparation. 本发明属于高分子功能材料技术领域，具体涉及种由多元醇甘油醚作为引发剂聚合环氧乙烷形成的新型窄分布/高纯度多臂聚乙二醇及其活性衍生物。所述的多臂聚乙二醇具有通式Ⅱ的结构，其中B为多元醇基，n为3-22的整数；PEG为相同或不同的-(OCHCH)-，m的平均值为3-250的整数，所述多臂聚乙二醇的数均分子量为1500-80000。本发明还提供了所述窄分布/高纯度多臂聚