Cell-Binding Agent Maytansinoid Conjugates Linked Via A Non-Cleavable Linker

• Main Authors: LUTZ ROBERT, XIE HONGSHENG, CHARI RAVI, KOVTUN YELENA, STEEVES RITA
• Format: Patent
• Language: Chinese; English
• Published: 26.09.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population. 本发明公开了种方法，用于将美登木素生物碱靶向选择细胞群，方法包括：用细胞结合剂美登木素生物碱偶联物接触怀疑含有所述选择细胞群的细胞群或组织，其中个或多个美登木素生物碱通过不可切割的接头共价连接于所述细胞结合剂，并且所述细胞结合剂结合选择细胞群中的细胞。