(18Beta,20beta)-24-hydroxy-glycyrrhetate and preparation method thereof

The invention discloses a (18beta,20beta)-24-hydroxy-glycyrrhetate and a preparation method thereof. The synergistic combination effect of strong-acid cation exchange resin and hydrochloride or sulfate is used to substitute the catalysis effect of a traditional strong acid, so the preparation method...

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Bibliographic Details
Main Authors JI HAO, KONG FANBO, ZHANG YU, YU YANYAN, DOU CHANGQING, XU JUAN, KAN JIANWEI
Format Patent
LanguageChinese
English
Published 15.09.2017
Subjects
APPARATUS THEREFOR
CHEMISTRY
DERIVATIVES THEREOF
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
STEROIDS
SUGARS
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Summary:The invention discloses a (18beta,20beta)-24-hydroxy-glycyrrhetate and a preparation method thereof. The synergistic combination effect of strong-acid cation exchange resin and hydrochloride or sulfate is used to substitute the catalysis effect of a traditional strong acid, so the preparation method is simple, the use of a strong acid solution is avoided, high-temperature and high-pressure sharp reaction conditions are avoided, and the reaction safety is improved; the cation exchange resin can convert a raw material glycyrrhetate into a glycyrrhizic acid form easy to react, and can be repeatedly used multiple times, so the method has the advantages of low carbon environmental protection, cost reduction, short technologic cycle, simplicity and convenience in operation, and stable product quality. Compared with glycyrrhizic acid, the prepared (18beta,20beta)-24-hydroxy-glycyrrhetate has the advantages of good biological and pharmacological activities, good absorption efficiency, good bioavailability, obvious pr
Bibliography:Application Number: CN20171442397