Method for synthesizing 3-aryl substituted indolizine

The invention discloses a method for synthesizing 3-aryl substituted indolizine. The method comprises the following steps: in an ionic liquid medium, performing in-situ generation of a bromination aryl methyl substituted pyridine quaternary ammonium salt from pyridine and aryl methyl bromide, and fu...

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Bibliographic Details
Main Authors ZHANG XIAO, LU GUOPING, SUN KANGKANG
Format Patent
LanguageChinese
English
Published 08.09.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a method for synthesizing 3-aryl substituted indolizine. The method comprises the following steps: in an ionic liquid medium, performing in-situ generation of a bromination aryl methyl substituted pyridine quaternary ammonium salt from pyridine and aryl methyl bromide, and further performing 1,3-dipolar-cycloaddition reaction with electron-deficiency alkyne under an alkali condition, so as to obtain a target product. Compared with a conventional synthesis method, the method has the remarkable advantages that firstly, reaction conditions are simple, and no transition metal catalyst is used; secondly, reaction conditions are gentle, and reaction reagents are relatively safe and cheap; thirdly, the solvent used in the reaction is an ionic liquid which has the advantages of being low in steam pressure, not liable to combustion or explosion, recyclable and the like. 本发明公开了种合成3-芳基取代吲哚嗪的方法。所述方法在离子液体介质中，利用吡啶和芳甲基溴原位生成溴化芳甲基取代吡啶季铵盐，再在碱性条件下与缺电子炔烃发生1,3-偶极环加成反应得到目标产物。相比于传统的合成方法，本发明具有显著的优点：(1)反应条件简单且
Bibliography:Application Number: CN20171483979