Arteriosclerosis and cancer detection method using deoxyhypusine synthase gene as indicator

• Main Authors: NAKAMURA RIKA, HIWASA TAKAKI, SAEKI NAOKATSU, TOMIYOSHI GO, KURODA HIDEYUKI, TAKIGUCHI MASAKI
• Format: Patent
• Language: Chinese; English
• Published: 29.08.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The inventors of the present invention arrived at the present invention by discovering that the deoxyhypusine synthase (DHPS) gene, which has been reported to be connected to such cancers as prostate cancer and cervical cancer, is surprisingly very highly correlated with arteriosclerosis and digestive system cancers and can be used as a desired marker for arteriosclerosis and digestive system cancers. Specifically, the present invention provides a detection method for arteriosclerosis and digestive system cancers that verifies the expression of the deoxyhypusine synthase gene in a test sample, preferably a blood specimen, and that detects arteriosclerosis and digestive system cancers in a test subject using enhanced expression of said gene as an indicator. 本发明人发现，以往被报告与前列腺癌或子宫颈癌关联的脱氧羟腐胺缩赖氨酸合酶(DHPS)基因，令人惊讶地，与动脉硬化及消化系统癌非常良好地关联，能作为期望的动脉硬化及消化系统癌的标志物使用，完成本发明。具体而言，本发明提供在所述受试试样中确认在受试试样、优选为血液受试体中的脱氧羟腐胺缩赖氨酸合酶基因的表达，以所述基因表达的亢进作为指标检测受试者的动脉硬化及消化系统癌的动脉硬化及消化系统癌的检测方法。