Cyclic dinucleotides useful for the treatment of inter alia cancer

• Main Authors: CHAMPIGNY AURELIE CECILE, TAPE DANIEL TERENCE, COE DIANE MARY, BIGGADIKE KEITH, NEEDHAM DEBORAH
• Format: Patent
• Language: Chinese; English
• Published: 29.08.2017
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

A compound of formula (I) Or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants. 种式（I）的化合物或其药学上可接受的盐和互变异构体，含有所述化合物的组合物、组合产品和药物，以及它们的制备方法。本发明还涉及所述化合物、组合产品、组合物和药物在治疗STING（干扰素基因刺激蛋白）的调节是有益的疾病和病症中的用途，例如炎症，过敏性和自身免疫性疾病，感染性疾病，癌症，癌前综合征，以及作为疫苗佐剂。