Agents, uses and methods

The present invention relates to therapeutic agents for the targeted delivery of an immunosuppressive agent to monocytes and/or monocyte-derived cells comprising a binding moiety with specificity for monocytes and/or monocyte-derived cells and an immunosuppressive agent. In one embodiment, the agent...

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Main Authors CHRISTENSEN PETER ASTRUP, ANTON GABRIELE, GRAVERSEN NIELS JONAS HEILSKOV, SVENDSEN PIA, MOELLER HOLGER JON, MOESTRUP SOEREN KRAGH
Format Patent
LanguageChinese
English
Published 29.08.2017
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to therapeutic agents for the targeted delivery of an immunosuppressive agent to monocytes and/or monocyte-derived cells comprising a binding moiety with specificity for monocytes and/or monocyte-derived cells and an immunosuppressive agent. In one embodiment, the agent is a glucocorticoid-antibody conjugate. The invention also relates to methods, uses, kits and compositions comprising such agents. 本发明涉及用于向单核细胞和/或衍生自单核细胞的细胞靶向递送免疫抑制剂的治疗剂，其包含免疫抑制剂和对单核细胞和/或衍生自单核细胞的细胞具有特异性的结合部分。在个实施方式中，所述治疗剂是糖皮质激素-抗体偶联物。本发明还涉及包含所述治疗剂的方法、用途、试剂盒和组合物。
Bibliography:Application Number: CN201611013570