Ciliary neurotrophic factor nasal delivery system and preparation method and use thereof

• Main Authors: FAN QIANGWEI, XIE HEZHI
• Format: Patent
• Language: Chinese; English
• Published: 18.08.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed is a CNTF intranasal preparation for treatment of obesity with an absorption enhancer added, improving the bioavailability of biomacromolecular drug nasal administration, wherein a macromolecular protein drug may be delivered into blood, reaching and exceeding the effective injection blood drug concentration. It shows significant weight loss effects on normal mice, diet-induced obesity (DIO) mice, and DIO rat body weight, more effective than subcutaneous administration and positive drugs in the market, in a dose dependent manner. Pharmacodynamic results show that the weight loss stability was significantly better than that of subcutaneous administration, and antibody production was significantly reduced, without causing weight rebound and anorexia reaction. The formulation significantly improves the bioavailability compared to ordinary intranasal formulations, and has a simple preparation process, and stable and controllable quality, and is suitable for industrial production. 种添加吸收促进剂的治疗肥胖的CNTF鼻腔给药制