3-cycloalkyl-prop-2-enamide derivatives

The invention relates to new 3-cycloalkyl-2-propenamide derivatives of formula (I): in which   R1 represents H or (C1-C3)alkyl,   W represents O or optionally oxidised S,   Y and Z represent -CH- or one of Y and Z represents -CH and the other represents N,   R2, R3, R4, R5 and R6 represent H, haloge...

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Bibliographic Details
Main Author ELIZABETH ANNE KUO
Format Patent
LanguageEnglish
Published 07.04.1993
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new 3-cycloalkyl-2-propenamide derivatives of formula (I): in which   R1 represents H or (C1-C3)alkyl,   W represents O or optionally oxidised S,   Y and Z represent -CH- or one of Y and Z represents -CH and the other represents N,   R2, R3, R4, R5 and R6 represent H, halogen, (C1-C4)alkyl, - OCH3, -SCH3, -WCF3, NO2, CN, -W(CH2)n-CF3, -W(CF2)n-CF3 , -(CH2)n-CX3 or -(CF2)n-CF3, in which n is 1, 2 or 3 and X represents halogen or R3 and R4 together form -O-CH2-O-,   R7 and R8 represent H or (C1-C6)alkyl,   R9 represents (C3-C6)cycloalkyl, to their tautomeric forms and to their addition salts with bases, as well as to their process of preparation, to their application as medicaments and to the compositions which contain them.
Bibliography:Application Number: CN19921010722