Method used for screening anacerobe traditional Chinese medicine inhibitors based on CoFeB nanoprobe

• Main Authors: ZOU DENGCHAO, ZHENG HONGLI, WAN YIQIN, ZHAO RU, ZHANG JINSHENG, PENG HONG, WU XIAODAN
• Format: Patent
• Language: Chinese; English
• Published: 15.08.2017
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses a method used for screening anacerobe traditional Chinese medicine inhibitors based on a CoFeB nanoprobe, and belongs to the technical field of traditional Chinese medicine development and application. According to the method, a paramagnetic CoFeB nanoprobe prepared via antibody coating is capable of realizing specific binding with a target bacterium, and nuclear magnetic resonance relaxation time is influenced by the paramagnetism of CoFeB, so that it is possible to detect whether a sample contains the target bacterium. The content of nano CoFeB of the paramagnetic CoFeB nanoprobe and the nuclear magnetic resonance relaxation time are linearly dependent in a certain range, the higher the nano CoFeB content, the smaller the nuclear magnetic resonance spin-lattice relaxation time and the spin-spin relaxation time, quantitative determination of the target bacterium can be realized in a certain range, and indirect evaluation of antibacterial effect of a traditional Chinese medicine formul