Method for preparing trans-3-methyl-5-benzyl aminopiperidine

The present invention provides a method for preparing trans-3-methyl-5-benzyl aminopiperidine, and in particular the method is as follows: an intermediate type (e) compound is prepared, then the trans-3-methyl-5-benzyl aminopiperidine is prepared by chiral inversion substitution reaction of the inte...

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Bibliographic Details
Main Authors SHENG LI, SHEN RUNPU, JIN QIXIN, WU GUOFENG, ZOU XIANYAN, FENG GAOFENG
Format Patent
LanguageChinese
English
Published 08.08.2017
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a method for preparing trans-3-methyl-5-benzyl aminopiperidine, and in particular the method is as follows: an intermediate type (e) compound is prepared, then the trans-3-methyl-5-benzyl aminopiperidine is prepared by chiral inversion substitution reaction of the intermediate type (e) compound, and groups are as described in the specification. The method has the advantages of simple easily-obtained raw material, simple process, convenient operation, mild reaction conditions and the like. 本发明提供了种反式-3-甲基-5-苄基氨基哌啶的制备方法，具体地，所述方法通过制备中间体式(e)化合物，进而通过手性翻转的取代反应从而得到反式-3-甲基-5-苄基氨基哌啶；其中，各基团的定义如说明书中所述。本发明具有原料简单易得、工艺简单、操作方便、反应条件温和等优点。
Bibliography:Application Number: CN2016177103