Costimulatory chimeric antigen receptor t cells targeting Il13Ralpha2

• Main Authors: BROWN CHRISTINE E, FORMAN STEPHEN J
• Format: Patent
• Language: Chinese; English
• Published: 01.08.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain that includes IL-13 or a variant thereof that binds interleukin-13Ralpha2 (IL13Ralpha2), a transmembrane region, a costimulatory domain and an intracellular signaling domain are described. 描述了嵌合跨膜免疫受体(CAR)，其包含含有IL-13或其结合白介素-13Rα2(IL13Rα2)的变体的胞外域、跨膜区、共刺激域和胞内信号传导域。