Metal complex formulations

• Main Authors: MEIJER ANDREAS RICHARD, THANING MIKKEL JACOB
• Format: Patent
• Language: Chinese; English
• Published: 01.08.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a method of preparation of formulations of lanthanide metal complexes of macrocyclic chelators which further comprise a small excess of free chelator. The method uses a solid phase-bound scavenger chelator to remove excess lanthanide metal ions, prior to the addition of a defined excess chelator. Also provided is a method of preparation of MRI contrast agents, together with solid-phase bound chelator meglumine salts useful in the methods. 本发明涉及种制备大环螯合物的镧系金属络合物的制剂的方法，所述制剂还包含小过量的游离螯合剂。该方法使用固相结合的清除剂螯合剂以除去过量的镧系金属离子，然后加入限定过量的螯合剂。本发明还提供可用于所述方法的与固相结合的螯合剂葡甲胺盐起制备MRI造影剂的方法。