Metroprolol succinate crystal form and preparation method thereof

• Main Authors: JIN KAI, YAO JUN, SUN BINGHUI, FAN LINJING, QI JUNCAI, ZHANG YARAN, LI YUANYUAN
• Format: Patent
• Language: Chinese; English
• Published: 01.08.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a metroprolol succinate crystal form and a preparation method thereof. The metroprolol succinate crystal form disclosed by the invention has X-ray diffraction peaks at positions of 7.4+/-0.2, 14.4+/-0.2, 20.4+/-0.2, 21.5+/-0.2 and 24.4+/-0.2 in a reflection angle of 2 theta. The metroprolol succinate crystal form disclosed by the invention has high content (or purity), low impurity content and stable quality and provides safety guarantee for clinical application of metroprolol succinate medicine. 本发明公开了种琥珀酸美托洛尔的晶型及其制备方法，本发明的琥珀酸美托洛尔晶型X-射线衍射在反射角2θ为：7.4±0.2、14.4±0.2、20.4±0.2、21.5±0.2、24.4±0.2处有峰。本发明的琥珀酸美托洛尔晶型含量(或纯度)高、杂质含量低、质量稳定，为琥珀酸美托洛尔药品的临床应用提供了安全保障。