Preparation method and application of chiral dihydroflavone compound and derivatives thereof

• Main Authors: LU ZHIWU, WANG JUN, XIONG DONGLU, ZHOU WENQIAN
• Format: Patent
• Language: Chinese; English
• Published: 25.07.2017
• Subjects: APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL METHODS OF ORGANIC CHEMISTRY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention provides a preparation method and application of a chiral dihydroflavone compound and derivatives thereof. The preparation method includes: a raw material as shown in formula I is allowed to have asymmetric hydrogen transfer reaction under the catalyzing of a non-noble-metal silicon-hydrogen catalyst to obtain the chiral dihydroflavone compound and derivatives thereof as shown in formula II. The preparation method has the advantages that cheap non-noble-metal silicon-hydrogen catalyst is used, low cost and low influence on environments are achieved, silane is used as the hydrogen source, operation simpleness and safety are achieved, reaction steps are few, raw materials are easy to obtain, reaction conditions are mild, enanioselectivity reaches above 90% and even reaches up to more than 94%, high yield is achieved, the yield can reach above 80%, the enanioselectivity and yield of the product are increased greatly, and the prepared chiral dihydroflavone compound and derivatives thereof are widely