Preparation method of beta-2, 6-didehydro-sugar aryl-C-glucoside

• Main Authors: ZHANG JIANBO, ZHANG WAN, SUN GUOSHENG, QIU SAIFENG
• Format: Patent
• Language: Chinese; English
• Published: 21.07.2017
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention discloses a preparation method of beta-2, 6-didehydro-sugar aryl-C-glucoside. The preparation method is characterized in that the method includes steps of taking desoxy-sugar replaced by different protection groups as a donor, and 1-naphthol, 2- naphthol, 4-methoxy-1- naphthol, 5-methoxy-1- naphthol or 1, 5- naphthalene dimethoxy as a receptor; mixing the donor and the receptor at the equivalence ratio of 1: 1.0-5.0; under the mixing, adding acetonitrile, dichloromethane, or 1, 2- dichloroethane; then performing glycosylation reaction under the I2-Et3SiH catalyst system. Compared with the prior art, the method is simple in technique, convenient to operate, low in production cost, high in yield, high in three-dimensional selectivity, more gentle in reaction condition, short in reaction time and others; the method avoids the environment pollution by high-toxic chemical raw material; therefore, it is green, environment-friendly, economic and high-efficient preparation method of beta-2, 6-didehydro-