Positive allosteric modulators of nicotinic acetylcholine receptor

• Main Authors: SAMS ANETTE GRAVEN, ESKILDSEN JORGEN, PUSCHL ASK
• Format: Patent
• Language: Chinese; English
• Published: 21.07.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compounds of formula (I) useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine a7 receptor. 本发明涉及烟碱乙酰胆碱受体的正变构调节剂。本发明还涉及可用于治疗的式(I)的化合物、涉及包含所述化合物的组合物和涉及包括施用所述化合物的治疗疾病的方法。提及的化合物是烟碱乙酷胆碱α7受体的正变构调节剂(PAM)。