Compound for inhibiting ROCK (Rho-associated coiled-coil containing protein kinase), and preparation method and application of compound

The invention discloses a compound shown as a formula (I) as shown in the description, or a stereoisomer, pharmaceutically acceptable salt, a crystal form, a solvate or an isotopologue of the compound. The invention further provides a preparation method of the compound and an application of the comp...

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Bibliographic Details
Main Authors ZHU WEIWEI, LIU SHAOJUN, CAI LONGYING, LI JIN, WAN JINQIAO, LI LINLI, DOU DENGFENG, LYU PENG, ZHANG LIFANG
Format Patent
LanguageChinese
English
Published 07.07.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a compound shown as a formula (I) as shown in the description, or a stereoisomer, pharmaceutically acceptable salt, a crystal form, a solvate or an isotopologue of the compound. The invention further provides a preparation method of the compound and an application of the compound in preparation of a drug for inhibiting ROCK (Rho-associated coiled-coil containing protein kinase). 本发明公开了式Ⅰ所示的化合物、或其立体异构体、或其药学上可接受的盐、或其晶型、或其溶剂合物、或其同位素体。本发明还提供了所述化合物的制备方法及其在制备抑制ROCK的药物中的应用。
Bibliography:Application Number: CN201611198408