Preparation method of tablet containing phentermine hydrochloride-topiramate

• Main Authors: YAN LIQUN, DENG RUOHAN, AN SHIZHI, ZHOU SHIWANG
• Format: Patent
• Language: Chinese; English
• Published: 23.06.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a preparation method of a tablet containing phentermine hydrochloride-topiramate. The preparation method comprises the following steps: preparing a rapid-release part, preparing a slow-release part, and carrying out tabletting. For the tablet, topiramate is taken as the slow-release part, and phentermine hydrochloride is taken as the rapid-release part. With the adoption of the preparation method, the problems that for the common controlled-release pellets, the process is complicated and the control is difficult during large-scale production are solved, and the preparation method provided by the invention is simple and is suitable for industrial mass production, thus having very good application prospects. 本发明提供了种含盐酸芬特明-托吡酯片剂的制备方法，包括：速释部分、缓释部分、压片等步骤：该片剂其中托吡酯为缓释部分，盐酸芬特明为速释部分。本发明解决了般缓释微丸工艺复杂且放大生产中不易控制的问题，本产品制备方法简单，适宜于工业化大生产，具有很好的应用前景。