Method for synthesizing 6-alkyl-2-oxo-1, 2-dihydroquinoline-3-carboxylic acid

The invention discloses a method for synthesizing 6-alkyl-2-oxo-1, 2-dihydroquinoline-3-carboxylic acid. The method comprises that 5-alkyl-2-nitrobenzaldehyde as a starting raw material instead of p-methylaniline undergoes an ester ammonolysis reaction to form a quinoline ring. The above process rep...

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Bibliographic Details
Main Authors LIU XIAOLEI, YANG TAO, ZHANG YAN, CUI YU, HAN JIXUN, SUN GUOXIN, YANG ZHEN
Format Patent
LanguageChinese
English
Published 20.06.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a method for synthesizing 6-alkyl-2-oxo-1, 2-dihydroquinoline-3-carboxylic acid. The method comprises that 5-alkyl-2-nitrobenzaldehyde as a starting raw material instead of p-methylaniline undergoes an ester ammonolysis reaction to form a quinoline ring. The above process replaces a Vilsmeier-Haack-Arnold electrophilic cyclization process. The method does not use virulent phosphorus oxychloride and discharges a small amount of post-treatment waste water. The finished product is obtained by hydrolysis of the ester, the process control is simple, the purification is convenient and the yield is high. The method for synthesis of 6-alkyl-2-oxo-1, 2-dihydroquinoline-3-carboxylic acid from 5-alkyl-2-nitrobenzaldehyde has the advantages of simple synthesis processes, no use of virulent phosphorus oxychloride and no coating of the raw materials. Compared with the traditional synthesizing method, the method has a high yield and less waste water discharge and has an important practical applicatio
Bibliography:Application Number: CN20171192569