Preparation method of escitalopram process impurities
The invention relates to a preparation method of escitalopram process impurities. The preparation method comprises the following steps: hydrolyzing 5-cyanophthalein and then forming weinreb amide with N-methyl-N-methoxyamine, and reacting with a Grignard reagent of N, N-dimethylaminochloropropane to...
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Main Authors | , , |
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Format | Patent |
Language | Chinese English |
Published |
09.06.2017
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Subjects | |
Online Access | Get full text |
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Summary: | The invention relates to a preparation method of escitalopram process impurities. The preparation method comprises the following steps: hydrolyzing 5-cyanophthalein and then forming weinreb amide with N-methyl-N-methoxyamine, and reacting with a Grignard reagent of N, N-dimethylaminochloropropane to obtain the escitalopram process impurities. The preparation method of the escitalopram process impurities is simple in process and higher in yield.
本发明涉及种艾司西酞普兰工艺杂质的制备方法,通过5-氰基苯酞水解后与N-甲基-N-甲氧基胺形成weinreb酰胺,再与N,N-二甲氨基氯丙烷的格式试剂反应得到艾司西酞普兰工艺杂质,工艺简单,收率较高。。 |
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Bibliography: | Application Number: CN2017172534 |