Preparation method of escitalopram process impurities

The invention relates to a preparation method of escitalopram process impurities. The preparation method comprises the following steps: hydrolyzing 5-cyanophthalein and then forming weinreb amide with N-methyl-N-methoxyamine, and reacting with a Grignard reagent of N, N-dimethylaminochloropropane to...

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Bibliographic Details
Main Authors MA XIANG, ZHAO YUNPING, ZHAO GUOLEI
Format Patent
LanguageChinese
English
Published 09.06.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a preparation method of escitalopram process impurities. The preparation method comprises the following steps: hydrolyzing 5-cyanophthalein and then forming weinreb amide with N-methyl-N-methoxyamine, and reacting with a Grignard reagent of N, N-dimethylaminochloropropane to obtain the escitalopram process impurities. The preparation method of the escitalopram process impurities is simple in process and higher in yield. 本发明涉及种艾司西酞普兰工艺杂质的制备方法，通过5-氰基苯酞水解后与N-甲基-N-甲氧基胺形成weinreb酰胺，再与N,N-二甲氨基氯丙烷的格式试剂反应得到艾司西酞普兰工艺杂质，工艺简单，收率较高。。
Bibliography:Application Number: CN2017172534