Methods and systems for predicting alloreactivity in transplantation

• Main Authors: SCHLIEHE-DIECKS RALF, SPIERINGS HENDRIKUS THEODORUS
• Format: Patent
• Language: Chinese; English
• Published: 31.05.2017
• Subjects: INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention relates to a method, system and/or data structure for carrying out a computer implemented method for determining the numbers of predicted indirectly recognized HLA epitopes (PIRCHES) between one or more donors and one or more recipients of transplantation material. The method, system and data structure described herein allow the identification of permissible mismatches and therefore relatively safe transplantation material by analysing via a computer implemented method HLA-derived peptides of patient and donor. 本发明涉及种用于执行计算机实现的方法的方法、系统和/或数据结构，其中计算机实现的方法用于确定移植材料的个或多个受体与个或多个供体之间的预测的间接识别HLA表位(PIRCHES)的数量。在此所述的方法、系统和数据结构，通过经由计算机实现的方法来分析患者和供体的HLA衍生肽，使得能够识别可允许的错配，因而得到相对安全的移植材料。