Composition containing eicosapentaenoic acid alkyl ester, and method for producing same

• Main Authors: ARATO SHINGO, DOISAKI NOBUSHIGE, FUKAE TAKURO
• Format: Patent
• Language: Chinese; English
• Published: 31.05.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES; CANDLES; CHEMISTRY; DETERGENTS; ESSENTIAL OILS; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS,OILS, OR FATTY ACIDS OBTAINED THEREFROM; FATTY ACIDS FROM FATS, OILS OR WAXES; FATTY ACIDS THEREFROM; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFUMES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRODUCING (PRESSING, EXTRACTION), REFINING AND PRESERVINGFATS, FATTY SUBSTANCES (e.g. LANOLIN), FATTY OILS AND WAXES,INCLUDING EXTRACTION FROM WASTE MATERIALS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are: a composition containing 96-99 area% of eicosapentaenoic acid alkyl ester, the composition having an arachidonic acid alkyl ester content of 0.7 area% or less, and an eicosapentaenoic-acid-alkyl-ester mono-trans isomer content of 2.5 area% or less; and a method for producing a composition containing a high concentration of eicosapentaenoic acid alkyl ester, the method including performing precision distillation on a composition containing eicosapentaenoic acid alkyl ester, obtained by alkyl esterification of a raw material oil containing eicosapentaenoic acid, under a vacuum of 0.2 Torr or lower and a temperature of 190 DEG C or lower in the entire column, and performing a concentration treatment on the precision-distilled composition using chromatography. 种组合物，其含有二十碳五烯酸烷基酯96～99面积％，花生四烯酸烷基酯的含量为0.7面积％以下，二十碳五烯酸烷基酯的单反式体的含量为2.5面积％以下。种含有高浓度二十碳五烯酸烷基酯的组合物的制造方法，其包括：对于通过将含有二十碳五烯酸的原料油烷基酯化而得到的包含二十碳五烯酸烷基酯的组合物，在0.2Torr以下的真空度及全塔190℃以下的温度下进行精密蒸馏；对于精密蒸馏后的组合物，使用色谱进行浓缩处理。