Method for preparing AMG 416

A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis pa...

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Main Authors CHEN YING, JONES SIAN, LOWER ASHER, CROCKETT RICHARD, RANGANATHAN KRISHNAKUMAR, BEZEMER JEROEN, CUI SHENG, CROSSLEY KEVIN, HUANG LIANG
Format Patent
LanguageChinese
English
Published 31.05.2017
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease-mineral and bone disorder (CKD-MBD). 提供用于制备AMG416或其药学上可接受的盐的方法。AMG 416为合成的钙敏感受体的八氨基酸选择性肽拮抗剂。其开发作为患有慢性肾疾病-矿物质和骨病症(CKD-MBD)的血液透析患者中继发性甲状旁腺功能亢进症(SHPT)的静脉内治疗。
Bibliography:Application Number: CN201580029560