N-pyridinyl acetamide derivatives as Wnt signalling pathway inhibitors

• Main Authors: MATHIESON MICHAEL, BHAMRA INDER, TESTAR RICHARD, DONOGHUE CRAIG
• Format: Patent
• Language: Chinese; English
• Published: 31.05.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to N-pyridinyl acetamide derivatives as Wnt signalling pathway inhibitors. The invention relates to compounds. More specifically, the invention relates to compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In addition, the invention contemplates processes to prepare the compounds and uses of the compounds. The compounds of the invention may therefore be used in treating conditions mediated by the Wnt signalling pathway, for example treating cancer, sarcoma, melanoma, skin cancer, haematological tumors, lymphoma, carcinoma, and leukemia; or enhancing the effectiveness of an anti-cancer treatment. 本发明涉及化合物。更具体地，本发明涉及用作Wnt信号传送途径的抑制剂的化合物。具体地，本发明预期Porcupine(Porcn)的抑制剂。此外，本发明预期制备该化合物的方法和该化合物的用途。因此，本发明的化合物可以用于治疗由Wnt信号传送途径介导的状况，例如可以治疗癌症、肉瘤、黑色素瘤、皮肤癌、血液肿瘤、淋巴瘤、上皮癌和白血病；或增强抗癌治疗的效力。