Polyethylene glycol vitamin E succinate modified tigecycline loading silver nanoparticles as well as preparation and application
The invention provides polyethylene glycol vitamin E succinate modified tigecycline loading silver nanoparticles. First, under the stabilizing effect of polyethylene glycol vitamin E succinate, hollow silver nanoparticles are formed through kirkendall effect, and polyethylene glycol vitamin E succin...
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Main Authors | , , , |
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Format | Patent |
Language | Chinese English |
Published |
31.05.2017
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Subjects | |
Online Access | Get full text |
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Summary: | The invention provides polyethylene glycol vitamin E succinate modified tigecycline loading silver nanoparticles. First, under the stabilizing effect of polyethylene glycol vitamin E succinate, hollow silver nanoparticles are formed through kirkendall effect, and polyethylene glycol vitamin E succinate modified silver nanoparticles are synthesized, thus the stability of the hollow silver nanoparticles is improved, and toxicity caused by oxidation of the silver nanoparticles is reduced. An antibacterial drug tigecycline is effectively loaded by the hollow structure of polyethylene glycol vitamin E succinate modified tigecycline loading silver nanoparticles. With relatively small particle size, the nanoparticles can penetrate through the cell wall of bacteria, destroy cell membrane and enter cytoplasm; and through the synergistic antibacterial effect of silver nanoparticles and tigecycline, the minimal inhibitory concentration and minimal bactericidal concentration of a drug are remarkably reduced, and the drug |
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Bibliography: | Application Number: CN201710047249 |