A novel compound (ks 513) isolated from pseudolysimachion rotundum var. subintegrum, the composition comprising the same as an active ingredient for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof

• Main Authors: OH SEI-RYANG, YOO JI-SEOK, AHN KYUNG-SEOP, SONG HYUK-HWAN, SHIN DAE-HEE, RYOO BYUNG-HWAN, LEE HYEONG-KYU, RYU HYUNG-WON, LEE YONG-NAM, LEE SU-UI
• Format: Patent
• Language: Chinese; English
• Published: 24.05.2017
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a novel (1aS,1bS,2S,4S,5aR,6S,6aS)-1a-(hydroxymethyl)-4-methoxy-2-(((2S,3R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-6-yl 4-hydroxybenzoate} (KS-513), the isomer thereof, the pharmaceutically acceptable salt or solvates thereof, a composition comprising the same as an active ingredient for preventing or treating allergic disease, inflammatory disease, asthma or chronic obstructive pulmonary disease (COPD) and the use thereof. 本发明涉及新的(1aS,1bS,2S,4S,5aR,6S,6aS)-1a-(羟甲基)-4-甲氧基-2-(((2S,3R,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)八氢环氧乙烯并[2',3':4,5]环戊二烯并[1,2-c]吡喃-6-基-4-羟基苯甲酸酯(KS-513)、其异构体、其药学上可接受的盐或溶剂化物，用于预防或治疗变应性疾病、炎性疾病、哮喘或慢性阻塞性肺病(COPD)的包含该化合物、其异构体、其药学上可接受的盐或溶剂化物作为活性成分的组合物及它们的用途。