Amino-substituted isoxazoles

• Main Authors: ROTTMANN ANTJE, BARFACKER LARS, HEINRICH TOBIAS, SIEMEISTER GERHARD, STOCKIGT DETLEF, PRECHTL STEFAN
• Format: Patent
• Language: Chinese; English
• Published: 24.05.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to amino-substituted isoxazoles of general formula (I) in which A, R1 and R2 are as defined in the claims, to methods of preparing the compounds, to intermediate compounds useful for preparing the compounds, to pharmaceutical compositions and combinations comprising the compounds and to the use of the compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients. 本发明涉及通式(I)的氨基取代的异噁唑类：其中A、R1和R2如权利要求中所定义，涉及制备所述化合物的方法，涉及用于制备所述化合物的中间体化合物，涉及包含所述化合物的药物组合物和组合，和涉及所述化合物以单独试剂或与其它活性成分组合的形式用于制备药物组合物的用途，所述药物组合物用于治疗或预防疾病，特别是新生物。