Preparation method for 1-O-acetyl-3,4-di-O-benzyl-2,6-dideoxy-alpha-D-glucoside

The invention discloses a preparation method for 1-O-acetyl-3,4-di-O-benzyl-2, 6-dideoxy-alpha-D-glucoside. The preparation method is characterized by adopting a two-step method to synthesize 1-O-acetyl-3,4-di-O-benzyl-2,6-dideoxy-alpha-D-glucoside. The two-step method comprises the steps of dissolv...

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Bibliographic Details
Main Authors ZHANG JIANBO, ZHU QIUHUA, FANG SHIQI, QIU SAIFENG, GUO HONG
Format Patent
LanguageChinese
English
Published 17.05.2017
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The invention discloses a preparation method for 1-O-acetyl-3,4-di-O-benzyl-2, 6-dideoxy-alpha-D-glucoside. The preparation method is characterized by adopting a two-step method to synthesize 1-O-acetyl-3,4-di-O-benzyl-2,6-dideoxy-alpha-D-glucoside. The two-step method comprises the steps of dissolving 6-deoxy-D-glucal in N,N-dimethylformamide firstly, then adding sodium hydride and benzyl bromide to prepare 3,4-di-O-benzyl-6-dexoy-D-glucal, then dissolving 3,4-di-O-benzyl-6-dexoy-D-glucal in dichloromethane, adding acetic anhydride, acetic acid and hydrogen bromide acetum to conduct glycosylation to obtain 1-O-acetyl-3,4-di-O-benzyl-2,6-dideoxy-alpha-D-glucoside. Compared with the prior art, the preparation method for 1-O-acetyl-3,4-di-O-benzyl-2,6-dideoxy-alpha-D-glucoside has the advantages that the process is simple, the reagents used are all cheap and easily available, the production cost is low, the yield is high, the total yield can be improved by 60%, and high-toxic chemical reagents can be effectivel
Bibliography:Application Number: CN201611152670