Humanized anti-tau antibodies

• Main Authors: WEST TIM, CARR FRANCIS J, HOLGATE ROBERT GEORGE EDWARD, ATHWAL DILJEET S, JONES TIMOTHY D
• Format: Patent
• Language: Chinese; English
• Published: 10.05.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Provided herein is an isolated antibody or antigen-binding fragment that specifically binds tau, the antibody or fragment comprising a heavy chain variable (VH) region and a light chain variable (VL) region having amino acid sequences set forth herein. Also provided are methods of preventing or treating a tauopathy in a subject, comprising administering to a human in need of therapy for a tauopathy with one or more antibodies or fragments as described herein, wherein the antibodies or antigen-binding fragment are administered under conditions and in an amount effective to prevent or treat the tauopathy. 本文提供了特异性结合tau的分离的抗体或抗原结合片段，所述抗体或片段包含具有本文所述的氨基酸序列的重链可变(VH)区和轻链可变(VL)区。还提供了预防或治疗主体中的tau蛋白病变的方法，其包括向需要tau蛋白病变的疗法的人施用种或多种如本文所述的抗体或片段，其中所述抗体或抗原结合片段在有效地预防或治疗tau蛋白病变的条件和量下施用。