Process for large scale production of 1-isopropyl-3-{5- [1-(3-methoxypropyl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}- 1h-indazole oxalate

• Main Authors: NIROGI RAMAKRISHNA, MOHAMMED ABDUL RASHEED, JASTI VENKATESWARLU
• Format: Patent
• Language: Chinese; English
• Published: 26.04.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The present invention relates to a process suitable for adoption to large scale manufacture of l-IsopropyI-3-{5-[l1-(3-methoxypropyl) piperidin-4-yl]-[ 1,3,4] oxadiazol-2-yl}- 1H-indazole oxalate of formula (I), which is a selective 5-HT4 receptor ligand intended for the symptomatic treatment of Alzheimer's disease and other disorders of memory and cognition like Attention deficient hyperactivity, Parkinson's and Schizophrenia. 本发明涉及适用于大规模制备式(I)的1-异丙基-3-{5-[1-(3-甲氧基丙基)哌啶-4-基]-[1，3，4]噁二唑-2-基}-1H-吲唑草酸盐的方法，所述式(I)的1-异丙基-3-{5-[1-(3-甲氧基丙基)哌啶-4-基]-[1，3，4]噁二唑-2-基}-1H-吲唑草酸盐为选择性5-HT受体配体并且旨在用于阿尔茨海默病以及其他记忆和认知障碍(如注意缺陷多动障碍、帕金森病和神经分裂症)的对症治疗。