Method for preparing 2,4-disubstituted thiazoline compound from acyl chloride

• Main Authors: JIANG LIN, LIU YI, LI ZHI, YU LICHEN, DU YUGUO, XIE YICHUAN, LIU HUILI
• Format: Patent
• Language: Chinese; English
• Published: 26.04.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention provides a novel method for preparing 2,4-disubstituted thiazoline at high yield by firstly reacting acyl chloride serving as a raw material and beta-azide disulfide and also provides a general formula I and application of a product, namely a 2,4-disubstituted thiazoline compound. By using the method, the defects of synthesis complexity, high byproduct yield and slightly low yield of the existing method are overcome, and the method has the advantages of high yield (up to 90% or above), high repeatability and suitability for preparation on a relatively large scale. 本发明提供种首次以酰氯为原料与β-叠氮二硫化物反应，高收率制备2，4-二取代噻唑啉的新方法，同时也给出了产物2，4-二取代噻唑啉类化合物的通式I及其用途。该方法克服了已有方法合成复杂，副产物多，收率偏低的缺点，具有产率高（产率可达90%以上），重复性强，适合较大规模制备的优点。