Bromophenol-oxazole compound and its use in drug for treatment on diabetes mellitus type 2

The invention relates to a chemical total synthesis method of novel bromophenol-oxazole PTP1B and its use in a drug for treatment on diabetes mellitus type 2. The PTP1B inhibitor has a structural formula shown in the description. The compound improves insulin receptor sensibility through inhibiting...

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Bibliographic Details
Main Authors WANG LIJUN, SHI DAYONG, LI XIANGQIAN, JIANG BO
Format Patent
LanguageChinese
English
Published 26.04.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a chemical total synthesis method of novel bromophenol-oxazole PTP1B and its use in a drug for treatment on diabetes mellitus type 2. The PTP1B inhibitor has a structural formula shown in the description. The compound improves insulin receptor sensibility through inhibiting the activity of protein tyrosine phosphatase 1B and has good treatment effects on insulin resistance-type diabetes mellitus type 2. 本发明涉及类新型溴酚-噁唑类PTP1B的化学全合成方法以及其在治疗2型糖尿病药物中的应用，所述PTP1B抑制剂结构式如下：该类化合物通过抑制蛋白酪氨酸磷脂酶1B的活性，增强胰岛素受体敏感性，对胰岛素抵抗类2型糖尿病具有良好的治疗作用。
Bibliography:Application Number: CN201611096704