3D printing breviscapine orally disintegrating tablet and preparation method thereof

• Main Authors: CHEN HUOJI, ZHU HONGXIA, LIU QIANG, RUAN SHIFA, XIANG SHIJIAN, WENG LIDONG, AN BAICHAO, HONG JUNHUI, CAO SIWEI
• Format: Patent
• Language: Chinese; English
• Published: 22.03.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a 3D printing breviscapine orally disintegrating tablet and a preparation method of the 3D printing breviscapine orally disintegrating tablet. The preparation method comprises the following steps: according to weight percentage, uniformly mixing 10-30 % of breviscapine, 30-60 % of dextrin, 25-40 % of microcrystalline cellulose, 10-15 % of povidone, 0-0.5 % of superfine silica powder, and 0-0.5 % of a corrigent, and placing the mixture into a powder box; placing an adhesive into an ink box; according to the preset parameters, carrying out modeling, and introducing into a control system of a 3D printing rapid forming machine; outputting an instruction by the control system, and printing the breviscapine orally disintegrating tablet; and taking out the printed breviscapine orally disintegrating tablet after the dispersible tablet is adhered and dried, thus obtaining the 3D printing breviscapine orally disintegrating tablet. The breviscapine orally disintegrating tablet printed by adopting