Simple catalyzed preparation method of spiro derivatives

• Main Authors: CHU ZHAOLIAN, YUE CAIBO, WU SHENGHUA, ZHANG HENG
• Format: Patent
• Language: Chinese; English
• Published: 15.03.2017
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention discloses a simple catalyzed preparation method of spiro derivatives, and belongs to the technical field of ionic liquid catalysis. The molar ratio of isatin or ninhydrin, malononitrile and beta-diketone in preparation reaction is 1:1:1, the molar weight of acidic ionic liquid catalyst is 2-4% of that of isatin, the volume dose of 92% vol ethanol water, reactive solvent in milliliter is 4-6 times of the molar weight of isatin in millimole, and reaction time of reflux is 5-30min. After reaction is finished, spirooxindole derivatives or spiro-1,3-dioxaindan pyran derivatives are obtained by cooling to room temperature, performing suction filtration and washing filter residue with 92% ethanol water prior to vacuum drying. Compared with other methods using ionic liquid as catalyst to prepare spiro derivatives, the method has the advantages that catalyst is less in loss during recycling and capable of being recycled for multiple times, the product purification process is simple, the whole reaction pr