Photo-controlled removal of targets in vitro and in vivo

• Main Authors: CHOYKE PETER, KOBAYASHI HISATAKA, SCHNERMANN MARTIN JOHN
• Format: Patent
• Language: Chinese; English
• Published: 01.03.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

This disclosure provides IR700-molecule conjugates and methods of their use to remove (e.g., separate or isolate) a target from a sample in vivo or from a subject in vitro. It is shown herein that exposure of IR700 to near infrared (NIR) light removes a portion of IR700, changing it from a hydrophilic molecule, to one that is hydrophobic, resulting in aggregation of IR700 and anything bound to it. For example, the disclosed IR700-molecule conjugates and methods provide photo-controlled ways to control the pharmacokinetics of a drug in vivo, and can be used to remove undesired agents from environmental or food samples or to isolate target molecules in a laboratory. 本公开内容提供了IR700-分子缀合物及其用于在体内从样品中或在体外从受试者中移除(例如，分开或分离)靶标的方法。在本文中示出，使IR700暴露于近红外(NIR)光会移除IR700的部分，将其从亲水性分子改变为疏水性分子，导致IR700和结合至其的任何物质的聚集。例如，所公开的IR700-分子缀合物和方法提供了光控方式来控制药物在体内的药代动力学，并且可以用于从环境或食物样品中移除不需要的试剂或在实验室中分离靶标分子。