Phosphatidylinositol 3-kinase inhibitors

• Main Authors: KIM MUSONG, KAPLAN JOSHUA, PERRAULT STEPHANE, EVARTS JERRY, TREIBERG JENNIFER A, PURVIS LAFE J II, STEVENS KIRK L, PATEL LEENA, PHILLIPS GARY, NADUTHAMBI DEVAN
• Format: Patent
• Language: Chinese; English
• Published: 22.02.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides phosphatidylinositol 3-kinase PI3K inhibitors of a formula J or pharmaceutically acceptable salts thereof, in which A, n, m, R1, R2, R3, R4, R5, R6 and R7 are defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms. The present disclosure further provides pharmaceutical compositions that include a compound (J) or pharmaceutically acceptable salts thereof and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms. 本申请提供了式(J)的磷脂酰肌醇3-激酶(PI3K)抑制剂，或其药学上可接受的盐，其中A、n、m、R、R、R、R、R、R和R如本文所定义。这些化合物用于治疗由种或多种PI3K同工型介导的病症。本申请还提供了包含式(J)化合物或其药学上可接受的盐的药物组合物和使用这些化合物和组合物来治疗由种或多种PI3K同工型介导的病症的方法。