6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof

• Main Authors: PATEL MEENA V, PELTIER HILLARY, KOENIG JOHN R, WAKEFIELD BRIAN D, JINKERSON TAMMIE K, KORT MICHAEL E, DEGOEY DAVID A, LIU BO, MATULENKO MARK A, COWART MARLON D, SCANIO MARC J, NELSON DEREK W, BOGDAN ANDREW
• Format: Patent
• Language: Chinese; English
• Published: 22.02.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, R2, and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nav1.7 and/or Nav1.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions. 式（I）的化合物及其可药用盐、酯、酰胺或放射性标记形式，其中R、R和R如说明书中所限定，可用于治疗通过电压门控钠通道例如Na1.7和/或Na1.8来预防或减轻的病况或病症。公开了制造该化合物的方法。还公开了式（I）的化合物的药物组合物，以及使用此类化合物和组合物的方法。