PPAR gamma activating agent

• Main Authors: YAMASHITA YUSUKE, AN JIYEONG, YAMATSU ATSUSHI, TSUJINO YOSHIO, MASUTANI BUMBU, HARADA SEIYU
• Format: Patent
• Language: Chinese; English
• Published: 22.02.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This PPAR gamma activating agent is characterized by containing a butenolide compound represented by expression (1), or a pharmaceutically permissible salt thereof. [In formula expression (1), R1 is a hydrogen atom, a phosphate group, a fatty acid group, an alkyl group of 1-4 carbon atoms optionally and having a substituent, or a sugar residue optionally having a substituent, and R2 is a phenyl group, a methyl phenyl group, a dimethyl phenyl group, an ethylphenyl group, a benzyl group, a methylbenzyl group, a dimethylbenzyl group, an ethyl benzyl group, a phenethyl group, a methylphenethyl group, a dimethyl phenethyl group or an ethyl phenethyl group.] 种PPARγ活化剂，其特征在于，含有式(1)所表示的丁烯羟酸内酯化合物或其药学上容许的盐。式(1)中，R表示氢原子、磷酸基、脂肪酸基、也可以具有取代基的碳原子数为1～4的烷基或也可以具有取代基的糖残基，R表示苯基、甲基苯基、二甲基苯基、乙基苯基、苄基、甲基苄基、二甲基苄基、乙基苄基、苯乙基、甲基苯乙基、二甲基苯乙基或乙基苯乙基。