Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof

• Main Authors: OVED KFIR, EDEN ERAN
• Format: Patent
• Language: Chinese; English
• Published: 22.02.2017
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The present invention provides methods of detecting infection using biomarkers. The invention also provides purposes of an antibody used for detecting the expression level of MX dynamin-like GTP enzyme-1 (MX1) and an antibody used for detecting the expression level of a C-reactive protein (CRP) in preparation of a kit used for distinguishing between bacterial infection or mixed infection, and viral infection of objects, wherein the distinguishing is realized by employing a hyperplane, and the hyperplane is calculated by combination of measurements of the CRP and the MX1 of a training group. 本发明提供使用生物标记检测感染的方法。本发明还提供用于检测MX发动蛋白样GTP酶1(MX1)的表达水平的抗体以及用于检测C反应蛋白(CRP)的表达水平的抗体在制备用于区分对象中的细菌或混合感染与病毒感染的试剂盒中的用途，其中所述区分使用超平面实现，所述超平面通过将训练群的所述CRP和所述MX1的测量进行组合来计算。