Polymethoxylated flavones, composition and pharmaceutic preparation for preventing or treating obesity

• Main Authors: LIU EHU, XIE ZHISHEN, XIAO PINGTING
• Format: Patent
• Language: Chinese; English
• Published: 22.02.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses polymethoxylated flavones, composition and pharmaceutic preparation for preventing or treating obesity. Active ingredients of the drug for preventing or treating obesity comprise polymethoxylated flavones being 3,5,6,7,8,3',4'-heptemthoxyflavone. In addition, the pharmaceutic preparation for preventing or treating obesity includes a pharmaceutically acceptable vector or excipient and thus a pharmaceutically acceptable dosage form is made. Adipose tissue accumulation causes obesity. Experiments demonstrate that the 3,5,6,7,8,3',4'-heptemthoxyflavone (HMF) enables adipose tissues to decrease obviously without affecting food intake, thereby suppressing adipose tissue accumulation and thus preventing or treating obesity. 本发明公开了种多甲氧基黄酮、组合物及其制剂在预防或治疗肥胖中的应用，该用于预防或治疗肥胖的药物的活性成分包括多甲氧基黄酮，所述多甲氧基黄酮为3,5,6,7,8,3',4'-七甲氧基黄酮，还包括药学上可以接受的载体或赋形剂，制成药学上可以接受的剂型。脂肪组织的堆积会引起肥胖，本发明证实，3,5,6,7,8,3',4'-七甲氧基黄酮(HMF)不影响进食量，但可以显著缩小脂肪组织，抑制脂肪组织堆积，能预防或治疗肥胖。