Tenofovir alafenamide complex, preparation method therefor and use thereof

• Main Authors: ZHAO XIONG, DU QUANSHENG, LI XUECHAO, LIN ZHIZHONG, LUO JIE, GAO BINGKUN, XIANG ZHIXIANG, QIAN CHUNXIA, YUAN DAOYI, XU TONGLI, LI FANGQUN, SUN PENG
• Format: Patent
• Language: Chinese; English
• Published: 15.02.2017
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to tenofovir alafenamide complex represented by formula II. The present invention also relates to a preparation method for said tenofovir alafenamide complex, pharmaceutical compositions containing the tenofovir alafenamide complex, and uses of the tenofovir alafenamide complex in preparing medicines for preventing and/or treating virus infection, especially Hepatitis B Virus (HBV) and/or Human Immunodeficiency Virus (HIV) infection. 本发明涉及式Ⅱ所示的替诺福韦艾拉酚胺复合物。本发明还涉及所述替诺福韦艾拉酚胺复合物的制备方法，含有该替诺福韦艾拉酚胺复合物的药物组合物，以及该替诺福韦艾拉酚胺复合物在制备预防和/或治疗病毒感染，特别乙型肝炎病毒(HBV)和/或人类免疫缺陷病毒(HIV)感染的药物中的应用。