Polymethoxylated flavonoids for preventing or treating non-alcoholic fatty liver diseases, composition and medicine preparation thereof

• Main Authors: LIU EHU, XIE ZHISHEN, XIAO PINGTING
• Format: Patent
• Language: Chinese; English
• Published: 15.02.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses polymethoxylated flavonoids, a composition, and application of preparations thereof to prevent or treat non-alcoholic fatty liver diseases. The medicine for preventing or treating the non-alcoholic fatty liver diseases comprises the active ingredients of polymethoxylated flavonoids and pharmaceutically acceptable carriers or excipient, wherein the polymethoxylated flavonoids is 3,5,6,7,8,3',4'-heptemthoxyflavone; the medicine is prepared into a pharmaceutically acceptable dosage form. After giving HMF (hydroxymethyl furfural), the liver structure is greatly improved; the liver fat accumulation caused by high fat diet is reduced; the HMF high-concentration liver lipid droplets approach to the normal level; the results show that the 3,5,6,7,8,3',4'-heptemthoxyflavone can effectively improve the liver lipid accumulation, achieves the effect of preventing or treating the non-alcoholic fatty liver diseases, and has the dose-effect difference. 本发明公开了种多甲氧基黄酮、组合物及其制剂在预防或治疗非酒精性脂肪肝中的应用，该用于预防或治疗非