Composition capable of improving Azilsartan bioavailability and stability and preparation method of composition

• Main Authors: ZHAO HONG, YANG LI, ZOU LINGYAN, HUANG WENWU, SONG JIAQI, LUAN HANSEN, LUO WENQING
• Format: Patent
• Language: Chinese; English
• Published: 15.02.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a composition containing Azilsartan. The composition contains the Azilsartan and poloxamer, the particle size of the Azilsartan is not greater than 150mum, the surface of the Azilsartan is wrapped through the poloxamer, and the mass ratio of the Azilsartan to poloxamer is 4:0.5-5. The invention further provides a preparation method of the composition. The preparation method includes: allowing Azilsartan raw materials to pass through 100-mesh sieve to collect Azilsartan powder with the particle size not greater than 150mum; dissolving the poloxamer into a solution with water, wherein the poloxamer solution is 1%-35% (W/V) in concentration; adopting a fluidized bed to spray the poloxamer solution to the surface of the Azilsartan to obtain the Azilsartan particles; continuously drying the Azilsartan particles with the fluidized bed to allow the moisture after drying is not greater than 1.5%; evenly mixing with auxiliary materials acceptable medically to obtain tablets. By the arrangement,