Application of guanidino compound

• Main Authors: DONG WENXIN, GU FENGHUA, ZHANG MEIXUAN, LIU XIANG, CHEN JIA, WU TONG, LI MOYING
• Format: Patent
• Language: Chinese; English
• Published: 01.02.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an application of a guanidino compound represented by formula I or a pharmaceutically acceptable salt of the guanidino compound in the preparation of medicines for treating nervous system degenerative diseases. R in the formula I is hydrogen, a carboxyl group or a -C1~C5 alkyl-carboxyl group. The guanidino compound has a substantial protection effect on hydrogen peroxide induced neonatal rat hippocampal nerve cell injures, has a substantial inhibition effect on in vitro beta-amyloid protein aggregation, and has potential clinic application values. 本发明公开了种如式I所示的胍基化合物或其药学上可接受的盐在制备治疗神经系统退行性疾病的药物中的应用；其中，所述R为氢、羧基或-C～C烷基-羧基。本发明的胍基化合物在过氧化氢所致新生大鼠海马神经细胞损伤的保护作用及对体外β-淀粉样蛋白聚集的抑制作用中效果显著，具有潜在的临床应用价值。